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BMC Endocr Disord. 2018 Nov 6;18(1):81. doi: 10.1186/s12902-018-0310-y.

Bisphenol A exposure and type 2 diabetes mellitus risk: a meta-analysis.

Author information

1
Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.
2
Department of Public Health, Graduate School, Yonsei University, Seoul, Republic of Korea.
3
Department of Epidemiology and Health Promotion, Institute for Health Promotion, Graduate School of Public Health, Yonsei University, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea. jsunha@yuhs.ac.

Abstract

BACKGROUND:

This meta-analytic study explored the relationship between the risk of type 2 diabetes mellitus (T2DM) and bisphenol A concentrations.

METHODS:

The Embase and Medline (PubMed) databases were searched, using relevant keywords, for studies published between 1980 and 2018. A total of 16 studies, twelve cross-sectional, two case-control and one prospective, were included in the meta-analysis. The odds ratio (OR) and its 95% confidence interval (CI) were determined across the sixteen studies. The OR and its 95% CI of diabetes associated with bisphenol A were estimated using both fixed-effects and random-effects models.

RESULTS:

A total of 41,320 subjects were included. Fourteen of the sixteen studies included in the analysis provided measurements of urine bisphenol A levels and two study provided serum bisphenol A levels. Bisphenol A concentrations in human bio-specimens showed positive associations with T2DM risk (OR 1.28, 95% CI 1.14, 1.44). A sensitivity analysis indicated that urine bisphenol A concentrations were positively associated with T2DM risk (OR 1.20, 95% CI 1.09, 1.31).

CONCLUSIONS:

This meta-analysis indicated that Bisphenol A exposure is positively associated with T2DM risk in humans.

KEYWORDS:

Bisphenol a (BPA); Diabetes mellitus (DM); Endocrine disrupting chemicals (EDCs); Fasting plasma glucose; Hemoglobin A1c (HbA1c); Meta-analysis; Obesity; Type 2 diabetes mellitus (T2DM)

PMID:
30400886
PMCID:
PMC6219165
DOI:
10.1186/s12902-018-0310-y
[Indexed for MEDLINE]
Free PMC Article

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