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Brain Connect. 2018 Nov 6. doi: 10.1089/brain.2018.0600. [Epub ahead of print]

Effective Connectivity Within the Default Mode Network In Left Temporal Lobe Epilepsy: Findings from the Epilepsy Connectome Project.

Author information

1
University of Wisconsin-Madison, Medical Physics, Madison, Wisconsin, United States ; cjcook3@wisc.edu.
2
University of Wisconsin-Madison, Medical Physics , 1111 Highland Ave. , 1122-E1 , Madison, Wisconsin, United States , 53705 ; ghwang3@wisc.edu.
3
Medical College of Wisconsin, 5506, Radiology, Milwaukee, Wisconsin, United States ; jmathis@mcw.edu.
4
UW-Madison, Radiology , 1111 HIGHLAND AVE , WIMR , Madison, Wisconsin, United States , 53705 ; VNair@uwhealth.org.
5
Medical College of Wisconsin, Neurology , 9200 W. Wisconsin Ave. , Milwaukee, Wisconsin, United States , 53226 ; lconant@mcw.edu.
6
Froedtert and the Medical College of Wisconsin Froedtert Hospital, 20721, Neurology, Milwaukee, Wisconsin, United States ; linda.allen@froedtert.com.
7
University of Wisconsin-Madison, Neurology, Madison, Wisconsin, United States ; almane@neurology.wisc.edu.
8
UW Psychiatric Institute and Clinics School of Medicine and Public Health, Department of Psychiatry , 6001 Research Park Boulevard , PO Box 9601 , Madison, Wisconsin, United States , 53719 ; rbirn@wisc.edu.
9
Medical College of Wisconsin, 5506, Radiology , 8701 Watertown Plank Rd , Milwaukee, Wisconsin, United States , 53226-0509 ; deyoe@mcw.edu.
10
University of Wisconsin-Madison, Neurology, Madison, Wisconsin, United States ; felton@neurology.wisc.edu.
11
University of Wisconsin-Madison, Neurology, Madison, Wisconsin, United States ; forseth@neurology.wisc.edu.
12
Medical College of Wisconsin , 8701 Watertown Plank Rd , Milwaukee, United States , 53226 ; chumphri@mcw.edu.
13
Medical College of Wisconsin, 5506, Neurology, Milwaukee, Wisconsin, United States ; pkraegel@mcw.edu.
14
Medical College of Wisconsin, Biophysics , 8701 Watertown Plank Rd , Milwaukee, Wisconsin, United States , 53226 ; anencka@mcw.edu.
15
University of Wisconsin-Madison, Pharmacy, Madison, Wisconsin, United States ; onwoke@wisc.edu.
16
Medical College of Wisconsin, 5506, Neurology, Milwaukee, Wisconsin, United States ; mraghavan@mcw.edu.
17
University of Wisconsin-Madison, Neuroscience Training Program, Madison, Wisconsin, United States ; riverabonet@wisc.edu.
18
Medical College of Wisconsin, 5506, Neurology, Milwaukee, Wisconsin, United States ; mrozman@mcw.edu.
19
University of Wisconsin-Madison, Radiology, Madison, Wisconsin, United States ; tellapragada@wisc.edu.
20
Medical College of Wisconsin, 5506, Neurology, Milwaukee, Wisconsin, United States ; custine@mcw.edu.
21
Medical College of Wisconsin, Biophysics , 8701 Watertown Plank Road , Milwaukee, Wisconsin, United States , 53226 ; ward@mcw.edu.
22
University of Wisconsin-Madison, Neurology, Madison, Wisconsin, United States ; struck@neurology.wisc.edu.
23
University of Wisconsin-Madison, Neurology, Madison, Wisconsin, United States ; maganti@neurology.wisc.edu.
24
University of Wisconsin-Madison, Neurology, Madison, Wisconsin, United States ; hermann@neurology.wisc.edu.
25
University of Wisconsin, Radiology , 600 Highland Avenue , madison, Wisconsin, United States , 53792-3252 ; vprabhakaran@uwhealth.org.
26
Medical College of Wisconsin, 5506, Neurology, Milwaukee, Wisconsin, United States ; jbinder@mcw.edu.
27
University of Wisconsin, Neuroscience Training Program, Madison, Wisconsin, United States.
28
University of Wisconsin, Medical Physics, Madison, Wisconsin, United States ; memeyerand@wisc.edu.

Abstract

The Epilepsy Connectome Project examines the differences in connectomes between temporal lobe epilepsy (TLE) patients and healthy controls. Using this data, the effective connectivity of the default mode network in patients with left TLE compared to healthy controls was investigated using spectral dynamic causal modeling of resting state functional magnetic resonance imaging data. Group comparisons were made using two parametric empirical Bayes (PEB) models. The first level of each PEB model consisted of each participant's spectral dynamic causal modeling. Two different second level models were constructed: the first comparing effective connectivity of the groups directly and the second using the Rey Auditory Verbal Learning Test (RAVLT) delayed free recall index as a covariate at the second level in order to assess effective connectivity controlling for the poor memory performance of left TLE patients. After an automated search over the nested parameter space and thresholding parameters at 95% posterior probability, both models revealed numerous connections in the DMN which lead to inhibition of the left hippocampal formation. Left hippocampal formation inhibition may be an inherent result of the left temporal epileptogenic focus as memory differences were controlled for in one model and the same connections remained. An excitatory connection from the posterior cingulate cortex to the medial prefrontal cortex was found to be concomitant with left hippocampal formation inhibition in TLE patients when including RAVLT delayed free recall at the second level.

KEYWORDS:

Default mode network; Effective connectivity; Epilepsy; Functional magnetic resonance imaging (fMRI); Resting-state networks

PMID:
30398367
DOI:
10.1089/brain.2018.0600

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