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Anticancer Res. 2018 Nov;38(11):6217-6223. doi: 10.21873/anticanres.12976.

Oolong Tea Extract Induces DNA Damage and Cleavage and Inhibits Breast Cancer Cell Growth and Tumorigenesis.

Author information

1
Department of Oncology, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, P.R. China.
2
Division of Hematology/Oncology, Department of Internal Medicine, School of Medicine, Saint Louis University, Saint Louis, MO, U.S.A.
3
Division of Hematology/Oncology, Department of Internal Medicine, School of Medicine, Saint Louis University, Saint Louis, MO, U.S.A. chunfa.huang@health.slu.edu.

Abstract

BACKGROUND/AIM:

Breast cancer is the most prevalent and devastating malignant disease among women worldwide. Green tea has been extensively studied for its anti-cancer effects, however, existing literature on the correlation of other types of tea with breast cancer is very limited.

MATERIALS AND METHODS:

We used six different breast cancer cell lines (ER+, PR+ or HER2+ and triple-negative), treated under different concentrations of green, oolong, black and dark tea extracts, and determined their biological effects.

RESULTS:

We determined cell viability, observed the changes of cell morphology, measured DNA damage and cleavage, and analyzed the effect on soft agar colony formation and growth.

CONCLUSION:

Oolong tea, same as green tea, can induce DNA damage and cleavage, play an inhibitory role in breast cancer cell growth, proliferation and tumorigenesis, and was a great potential as a chemo-preventive agent against breast cancer.

KEYWORDS:

DNA damage and cleavage; Oolong tea; breast cancer; cell viability; soft agar colony formation

PMID:
30396940
DOI:
10.21873/anticanres.12976
[Indexed for MEDLINE]

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