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Pathol Res Pract. 2019 Jan;215(1):1-4. doi: 10.1016/j.prp.2018.10.027. Epub 2018 Oct 24.

Structural biology of intraepithelial neuroendocrine cells in the larynx: Literature review.

Author information

1
Department of Pathology, Liverpool Clinical Laboratories, Royal Liverpool University Hospital, Liverpool, UK; School of Dentistry, University of Liverpool, Liverpool, UK. Electronic address: A.Triantafyllou@liverpool.ac.uk.
2
Department of Pathology, Allegiance Health, Jackson, MI, USA.
3
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
4
University of Udine, School of Medicine, Udine, Italy.
5
Coordinator of the International Head and Neck Scientific Group, Padua, Italy.

Abstract

Current knowledge of laryngeal neuroendocrine cells in man and other vertebrates is reviewed. Particular attention is paid to differences in the distribution of neuroendocrine cells between squamous and respiratory laryngeal mucosa, foetal versus post-natal spatial arrangements, relation to the laryngeal cavity and nerve fibres, and immunoreactivities of these cells. Methodological deficiencies and gaps in knowledge are outlined. Comparisons with neuroendocrine cells in lung and gut are drawn, caution with regard to existing histogenetic models of laryngeal neuroendocrine neoplasia is advised and lines of future research are suggested.

KEYWORDS:

Electron microscopy; Histology; Immunohistochemistry; Larynx; Neuroendocrine cells

PMID:
30396757
DOI:
10.1016/j.prp.2018.10.027

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