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Hum Immunol. 2018 Nov 2. pii: S0198-8859(18)30926-1. doi: 10.1016/j.humimm.2018.10.004. [Epub ahead of print]

Does NGS typing highlight our understanding of HLA population diversity?: Some good reasons to say yes and a few to say be careful.

Author information

1
Department of Genetics and Evolution - Anthropology Unit, University of Geneva and Institute of Genetics and Genomics in Geneva (IGE3), Switzerland. Electronic address: Alicia.Sanchez-Mazas@unige.ch.
2
Department of Genetics and Evolution - Anthropology Unit, University of Geneva and Institute of Genetics and Genomics in Geneva (IGE3), Switzerland. Electronic address: Jose.deAbreuNunes@unige.ch.

Abstract

This paper discusses the advantages provided by next generation sequencing (NGS) compared to traditional typings or limited sequencing strategies for the characterization of HLA population diversity based on four documented examples. We also comment the limitations of this approach by highlighting pitfalls in interpreting NGS data.

KEYWORDS:

Disease associations; Evolutionary models; HLA; Molecular evolution; Next generation sequencing (NGS); Nucleotide diversity; Population genetics

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