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J Urol. 2019 May;201(5):987-993. doi: 10.1016/j.juro.2018.10.019.

Effect of Vitamin D Therapy on Sexual Function in Women with Sexual Dysfunction and Vitamin D Deficiency: A Randomized, Double-Blind, Placebo Controlled Clinical Trial.

Author information

1
Department of Midwifery and Reproductive Health and Students Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2
Department of Chronic Diseases, Metabolism and Ageing, University of Leuven, Leuven, Belgium.
3
Department of Nutrition, Faculty of Public Health, Iran University of Medical Sciences, Tehran, Iran.
4
Department of Biostatistics, Faculty of Paramedic, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5
Department of Nutrition, Faculty of Paramedic, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
6
Department of Midwifery and Reproductive Health, Midwifery and Reproductive Health Research Center, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract

PURPOSE:

We investigated the effect of vitamin D therapy on sexual function in women with low vitamin D levels and sexual dysfunction.

MATERIALS AND METHODS:

We performed this randomized, double-blind, placebo controlled trial in women 18 to 45 years old with sexual dysfunction, defined as a FSFI (Female Sexual Functioning Index) score less than 26.55, and serum 25[OH]D less than 30 ng/ml. Participants received an intramuscular injection of 300,000 IU cholecalciferol or a placebo at baseline and then after 4 weeks. Sexual function was evaluated with the FSFI at baseline, and 4 and 8 weeks. The serum level of 25[OH]D was measured and depression symptoms were evaluated by the BDI (Beck Depression Inventory) at baseline and 8 weeks.

RESULTS:

A total of 38 women in each group completed the study. Serum 25[OH]D levels increased only in the cholecalciferol group by a mean ± SD of 14.4 ± 3.2 ng/ml (p <0.001). The FSFI score was higher in the intervention group at study week 4 (19.6 vs 16.3, p = 0.002) and week 8 (25.0 vs 17.1, p <0.001). The BDI score was significantly decreased only in the cholecalciferol group by a mean of -21.0 ± 12.3 (p <0.001). The effect of treatment on sexual function was independent of its effect on depression symptoms.

CONCLUSIONS:

Vitamin D therapy in women with sexual dysfunction and vitamin D deficiency can improve sexual function. This effect does not seem to be mediated by an improvement in depression symptoms.

KEYWORDS:

depression; physiological; psychological; sexual dysfunction; sexual dysfunctions; vitamin D deficiency; women's health

Comment in

PMID:
30395842
DOI:
10.1016/j.juro.2018.10.019
[Indexed for MEDLINE]

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