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Pediatr Blood Cancer. 2018 Nov 4:e27532. doi: 10.1002/pbc.27532. [Epub ahead of print]

Sentinel lymph node biopsy in head and neck rhabdomyosarcoma.

Author information

1
Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
2
Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
3
Department of Radiation Oncology, University of Cincinnati, Cincinnati, Ohio.
4
Division of Pediatric General and Thoracic Surgery, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Abstract

Head and neck rhabdomyosarcoma lymph node staging is challenging due to varied patterns of lymphatic drainage and the suboptimal predictive value of available imaging modalities. Furthermore, regional relapse rates are unacceptably high, and the toxicity of empiric radiation is undesirable in the pediatric and young adult population. In an attempt to improve locoregional control without excess morbidity, we have adopted routine sentinel lymph node biopsy in head and neck rhabdomyosarcoma, which is safe and feasible in pediatric patients. Of six procedures reported here, pathologic findings led to intensification of regional and/or systemic therapy in two patients.

KEYWORDS:

head and neck; parameningeal; rhabdomyosarcoma; sentinel lymph node

PMID:
30393936
DOI:
10.1002/pbc.27532

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