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Therapie. 2018 Oct 19. pii: S0040-5957(18)30239-7. doi: 10.1016/j.therap.2018.08.002. [Epub ahead of print]

Interest of pharmacoepidemiology for the study of inhaled drugs.

Author information

1
Service of medical pharmacology, university of Bordeaux, CHU de Bordeaux, 33076 Bordeaux, France; Inserm, UMR 1219, Bordeaux population health research center, team pharmacoepidemiology, 33000 Bordeaux, France. Electronic address: mathieu.molimard@u-bordeaux.fr.
2
Service of medical pharmacology, university of Bordeaux, CHU de Bordeaux, 33076 Bordeaux, France.
3
EA 7425 HESPER health services and performance research, and PELyon, Claude-Bernard université, CIC 1401, 69424 Lyon, France; Respiratory medicine, Croix-Rousse hospital, 69317 Lyon, France.

Abstract

Pharmacoepidemiology studies are of particular interest in the respiratory field and especially for inhaled drugs. In real-life, excessive use of rescue medications and under- or inappropriate-prescribing of preventer medications has been shown. In asthma and chronic obstructive pulmonary disease (COPD), the poor use of inhalation device is associated with uncontrolled diseases and occurrence of exacerbations. Inhalation treatments are directly delivered within the lung and are generally considered as safe. However, systemic adverse drug reactions that were not evidenced in clinical trials may be observed after a long-term treatment.

KEYWORDS:

Asthma; COPD; Effectiveness; Inhalation; Real life

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