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Eur Arch Psychiatry Clin Neurosci. 2019 Oct;269(7):823-832. doi: 10.1007/s00406-018-0952-9. Epub 2018 Nov 3.

Combined cognitive, psychomotor and electrophysiological biomarkers in major depressive disorder.

Author information

1
Department of Psychiatry and Psychotherapy, Rostock University Medical Centre, Gehlsheimer Strasse 20, Rostock, 18147, Germany.
2
Institute for Experimental and Clinical Pharmacology and Toxicology, University of Luebeck, Ratzeburger Allee 160, Lübeck, 23562, Germany.
3
Department of Child and Adolescent Psychiatry, Neurology, Psychosomatics and Psychotherapy, Rostock University Medical Centre, Gehlsheimer Strasse 20, Rostock, 18147, Germany.
4
Department of Psychiatry and Psychotherapy, Rostock University Medical Centre, Gehlsheimer Strasse 20, Rostock, 18147, Germany. jacqueline.hoeppner@helios-gesundheit.de.
5
Hospital for Geriatric Psychiatry, Helios Kliniken Schwerin, Wismarsche Strasse 393-397, 19049, Schwerin, Germany. jacqueline.hoeppner@helios-gesundheit.de.

Abstract

The diagnosis of major depressive disorder (MDD) should be based on multimodal evidence, because MDD not only affects mood, but also psychomotor and cognitive functions. Clinical markers such as executive dysfunctions and a reduction in daily motor activity have been observed in MDD. Neurophysiological biomarkers have also been described. In this study, we investigate the utility of combining biomarkers related to executive dysfunctions, motor activity, neurophysiological patterns (i.e. alpha power asymmetry and EEG-vigilance as indicators of brain arousal), and the interaction of these parameters in the diagnosis of MDD. Twenty (female: 11) patients with MDD (age: 51.05 ± 10.50) and 20 (female: 13) healthy controls (HC; age: 47.15 ± 12.57) underwent a 10-min resting EEG. Executive dysfunctions were assessed using the Trail Making Test B (TMT B). Motor activity was analysed by actigraphy measurements. MDD patients displayed significant impairments in executive functions and reduced daily motor activity. In the EEG, MDD patients showed more right than left frontal activity and lower brain arousal relative to HC. TMT B and asymmetrical frontal alpha power alone discriminated between MDD patients and HC with an accuracy of 78%. The interaction of motor activity and the EEG-vigilance stage alongside TMT B increased the accuracy of the discrimination test to 81%. This improved accuracy suggests that the combination of these biomarkers in a discriminant analysis resulted in a more reliable identification of MDD patients.

KEYWORDS:

Actigraphy; Biomarkers; EEG; Executive dysfunction; Major depressive disorder

PMID:
30392042
DOI:
10.1007/s00406-018-0952-9

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