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Redox Biol. 2019 Jan;20:349-353. doi: 10.1016/j.redox.2018.10.004. Epub 2018 Oct 13.

Ascorbic acid metabolites are involved in intraocular pressure control in the general population.

Author information

1
Section of Academic Ophthalmology, Faculty of Life Sciences and Medicine, Kings' College London, UK; King's College London Department of Twin Research and Genetic Epidemiology, London, UK. Electronic address: pirro.hysi@kcl.ac.uk.
2
Department of Public Health & Primary Care, University of Cambridge, UK; NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital and University College London, UK.
3
King's College London Department of Twin Research and Genetic Epidemiology, London, UK.
4
University of California, San Francisco, School of Pharmacy, San Francisco, CA, USA.
5
Department of Public Health & Primary Care, University of Cambridge, UK.
6
NIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital and University College London, UK.
7
University of California, San Francisco, School of Pharmacy, Department of Bioengineering and Therapeutic Sciences, San Francisco, CA, USA.
8
Section of Academic Ophthalmology, Faculty of Life Sciences and Medicine, Kings' College London, UK; King's College London Department of Twin Research and Genetic Epidemiology, London, UK.

Abstract

Elevated intraocular pressure (IOP) is an important risk factor for glaucoma. Mechanisms involved in its homeostasis are not well understood, but associations between metabolic factors and IOP have been reported. To investigate the relationship between levels of circulating metabolites and IOP, we performed a metabolome-wide association using a machine learning algorithm, and then employing Mendelian Randomization models to further explore the strength and directionality of effect of the metabolites on IOP. We show that O-methylascorbate, a circulating Vitamin C metabolite, has a significant IOP-lowering effect, consistent with previous knowledge of the anti-hypertensive and anti-oxidative role of ascorbate compounds. These results enhance understanding of IOP control and may potentially benefit future IOP treatment and reduce vision loss from glaucoma.

KEYWORDS:

Ascorbate metabolism; Intraocular pressure; Multi-omics

PMID:
30391827
PMCID:
PMC6223183
DOI:
10.1016/j.redox.2018.10.004
[Indexed for MEDLINE]
Free PMC Article

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