Skeletal Manifestations of Hypoparathyroidism

Mishaela R Rubin

doi:10.1016/j.ecl.2018.07.008

Skeletal Manifestations of Hypoparathyroidism

Endocrinol Metab Clin North Am. 2018 Dec;47(4):825-837. doi: 10.1016/j.ecl.2018.07.008.

Author

Mishaela R Rubin¹

Affiliation

¹ Metabolic Bone Disease Unit, Columbia University College of P&S, PH8W-864, 630 West 168th Street, New York, NY 10032, USA. Electronic address: mrr6@columbia.edu.

PMID: 30390816
DOI: 10.1016/j.ecl.2018.07.008

Abstract

Chronic parathyroid hormone (PTH) deficiency has a marked effect on the skeleton, leading to characteristic decreases in bone remodeling and increases in bone mass. Numerous lines of evidence using biochemical, imaging, and histomorphometric methodologies have demonstrated that the skeleton is altered when PTH is absent and that these abnormalities might be reversed with PTH treatment. More evidence is needed to determine whether fracture risk is altered in hypoparathyroidism.

Keywords: Bone; Histomorphometry; Hypoparathyroidism; Imaging; rhPTH(1-84).

Publication types

Review

MeSH terms

Bone Density
Bone Diseases / drug therapy*
Bone Diseases / etiology*
Bone Remodeling
Bone and Bones / pathology*
Hormone Replacement Therapy
Humans
Hypoparathyroidism / complications*
Hypoparathyroidism / drug therapy
Hypoparathyroidism / pathology*
Parathyroid Hormone / therapeutic use
Skeleton*

Substances

Parathyroid Hormone