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Anesthesiol Clin. 2018 Dec;36(4):639-652. doi: 10.1016/j.anclin.2018.07.014. Epub 2018 Oct 12.

Genomics Testing and Personalized Medicine in the Preoperative Setting.

Author information

1
Division of Regional Anesthesia and Acute Pain, Department of Anesthesiology, University of California, San Diego, 200 W Arbor Dr, San Diego, CA 92103, USA; Department of Medicine, Division of Biomedical Informatics, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA. Electronic address: ragabriel@ucsd.edu.
2
School of Medicine, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093, USA.
3
Department of Anesthesiology, Perioperative and Pain Medicine, Harvard Medical School, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA.
4
Department of Anesthesiology, University of California, San Diego, 200 W Arbor Dr, San Diego, CA 92103, USA.

Abstract

Pharmacogenomics (PGx) is the study of how individuals' personal genotypes may affect their responses to various pharmacologic agents. The application of PGx principles in perioperative medicine is fairly novel. Challenges in executing PGx programs into health care systems include physician buy-in and integration into usual clinical workflow, including the electronic health record. This article discusses the current evidence highlighting the potential of PGx with various drug categories (including opioids, nonopioid analgesics, sedatives, β-blockers, antiemetics, and anticoagulants) used in the perioperative process and the challenges of integrating PGx into a health care system and relevant workflows.

KEYWORDS:

Genetics; Opioids; Outcomes; Pharmacogenomics; Preoperative

PMID:
30390784
DOI:
10.1016/j.anclin.2018.07.014
[Indexed for MEDLINE]

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