Format

Send to

Choose Destination
Clin Chest Med. 2018 Dec;39(4):677-689. doi: 10.1016/j.ccm.2018.07.003.

The Lung Microbiome and Its Role in Pneumonia.

Author information

1
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, NYU Human Microbiome Program, New York University School of Medicine, New York, NY 10028, USA.
2
Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, NYU Human Microbiome Program, New York University School of Medicine, New York, NY 10028, USA. Electronic address: Leopoldo.Segal@nyumc.org.

Abstract

The use of next-generation sequencing and multiomic analysis reveals new insights on the identity of microbes in the lower airways blurring the lines between commensals and pathogens. Microbes are not found in isolation; rather they form complex metacommunities where microbe-host and microbe-microbe interactions play important roles on the host susceptibility to pathogens. In addition, the lower airway microbiota exert significant effects on host immune tone. Thus, this review highlights the roles that microbes in the respiratory tract play in the development of pneumonia.

KEYWORDS:

Antibiotics; Bacterial taxa; Immune responses; Inflammation; Lung; Microbiome

PMID:
30390741
PMCID:
PMC6221463
[Available on 2019-12-01]
DOI:
10.1016/j.ccm.2018.07.003
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center