RETRACTED: Protective autophagy induced by physcion suppresses hepatocellular carcinoma cell metastasis by inactivating the JAK2/STAT3 Axis

Life Sci. 2018 Dec 1:214:124-135. doi: 10.1016/j.lfs.2018.10.064. Epub 2018 Oct 30.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief and the authors, as panels from Figure 6F appear as similar to panels from Figure 2B of the article published by Ming-Quan Gao, Hui Gao, Mei Han, Kai-Li Liu, Jian-Jun Peng and Yan-Tao Han in the American Journal of Cancer Research 7 (2017) 1501–1514 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523031/ and Figures 2E and 3E of the article published by Meizhi Wang, Hui Gao, Haijun Qu, Jing Li, Kaili Liu and Zhiwu Han in Pharmacological Reports 70 (2018) 963–971 https://doi.org/10.1016/j.pharep.2018.04.006. Also, the Vehicle panel from Figure 7E appears as similar to the Vehicle panel from Figure 3D of the article published by Bo Liu and Shuo Yu in Biomedicine & Pharmacotherapy 107 (2018) 243–253 https://doi.org/10.1016/j.biopha.2018.07.177. Figure 7E appears also as similar to Figure 6(b) of the article published by Mei Han, Hui Gao, Jing Xie, Yin-ping Yuan, Quan Yuan, Ming-quan Gao, Kai-li Liu, Xue-hong Chen, Yan-tao Han and Zhi-wu Han in Acta Pharmacologica Sinica volume 40 (2019) 666–676 https://doi.org/10.1038/s41401-018-0159-7. Moreover, panels from Figure 7F appear as similar to panels from Figure 7E of the Reference [1], Figure 6D of the Reference [2], Figure 6C of the Reference [3], Figure 8C of the Reference [4], Figure 8D of the Reference [5] and Figure 6B of the Reference [6]. One of the conditions of submission of a paper for publication is that authors declare explicitly that their work is original and has not appeared in a publication elsewhere. Re-use of any data should be appropriately cited. As such this article represents a severe abuse of the scientific publishing system. The scientific community takes a very strong view on this matter and apologies are offered to readers of the journal that this was not detected during the submission process.

Keywords: Apoptosis; HCC; Metastasis; Physcion; Protective autophagy.

Publication types

  • Retracted Publication

MeSH terms

  • Animals
  • Apoptosis / drug effects
  • Autophagy / drug effects*
  • Carcinoma, Hepatocellular / drug therapy*
  • Carcinoma, Hepatocellular / metabolism
  • Carcinoma, Hepatocellular / pathology
  • Cell Line, Tumor
  • Cell Movement / drug effects
  • Emodin / analogs & derivatives*
  • Emodin / pharmacology
  • Humans
  • Janus Kinase 2 / metabolism
  • Liver Neoplasms / drug therapy*
  • Liver Neoplasms / metabolism
  • Liver Neoplasms / pathology
  • Male
  • Mice, Inbred BALB C
  • STAT3 Transcription Factor / metabolism
  • Xenograft Model Antitumor Assays

Substances

  • STAT3 Transcription Factor
  • STAT3 protein, human
  • JAK2 protein, human
  • Janus Kinase 2
  • physcione
  • Emodin