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Int J Mol Sci. 2018 Nov 1;19(11). pii: E3432. doi: 10.3390/ijms19113432.

The Antitumor Natural Compound Falcarindiol Disrupts Neural Stem Cell Homeostasis by Suppressing Notch Pathway.

Author information

1
Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea. toy5988@naver.com.
2
National Development Institute of Korean Medicine, Gyeongsan, Gyeongsangbuk-do 38540, Korea. sook4269@naver.com.
3
Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea. alsrb5788@naver.com.
4
National Development Institute of Korean Medicine, Gyeongsan, Gyeongsangbuk-do 38540, Korea. ms_hee@naver.com.
5
Department of Cosmetic Science and Technology, College of Bio-industry, Daegu Haany University, Gyeongsan 38610, Korea. kyungha.lee@dhu.ac.kr.
6
Department of Pharmacology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, Daegu 41940, Korea. dykim82@knu.ac.kr.

Abstract

Neural stem cells (NSCs) are undifferentiated, multi-potent cells that can give rise to functional neurons and glial cells. The disruption in NSC homeostasis and/or the impaired neurogenesis lead to diverse neurological diseases, including depression, dementia, and neurodegenerative disorders. Falcarindiol (FAD) is a polyacetylene found in many plants, and FAD shows the cytotoxicity against breast cancers and colon cancers. However, there is no research on the consequence of FAD treatment in normal stem cells. Here, we suggest that FAD has anticancer roles against glioblastoma cells by inducing the differentiation of glioblastoma stem-like cells, as well as activating apoptosis pathway in glioblastoma cells. On the other hand, we also show that FAD has detrimental effects by disrupting the maintenance of normal NSCs and altering the balance between self-renewal and differentiation of NSCs.

KEYWORDS:

Notch pathway; apoptosis; differentiation; falcarindiol; neural stem cell

PMID:
30388862
PMCID:
PMC6274977
DOI:
10.3390/ijms19113432
[Indexed for MEDLINE]
Free PMC Article

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