Format

Send to

Choose Destination
Cell. 2018 Nov 1;175(4):962-972.e10. doi: 10.1016/j.cell.2018.10.029.

US Immigration Westernizes the Human Gut Microbiome.

Author information

1
Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN 55455, USA.
2
Biotechnology Institute, University of Minnesota, Minneapolis, MN 55455, USA.
3
Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA.
4
Center for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN 55455, USA.
5
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55902, USA.
6
Somali, Latino, and Hmong Partnership for Health and Wellness, West Side Community Health Services, St. Paul, MN 55106, USA.
7
Department of Mathematics, Statistics, and Computer Science, Macalester College, St. Paul, MN 55105, USA.
8
College of Biological Sciences, University of Minnesota, Minneapolis, MN 55455, USA.
9
Department of Microbiology & Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
10
Department of Family Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
11
Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot 63110, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Old Road Campus, Oxford OX3 7BN, UK.
12
Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, MN 55455, USA; Biotechnology Institute, University of Minnesota, Minneapolis, MN 55455, USA; Department of Computer Science and Engineering, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: dknights@umn.edu.

Abstract

Many US immigrant populations develop metabolic diseases post immigration, but the causes are not well understood. Although the microbiome plays a role in metabolic disease, there have been no studies measuring the effects of US immigration on the gut microbiome. We collected stool, dietary recalls, and anthropometrics from 514 Hmong and Karen individuals living in Thailand and the United States, including first- and second-generation immigrants and 19 Karen individuals sampled before and after immigration, as well as from 36 US-born European American individuals. Using 16S and deep shotgun metagenomic DNA sequencing, we found that migration from a non-Western country to the United States is associated with immediate loss of gut microbiome diversity and function in which US-associated strains and functions displace native strains and functions. These effects increase with duration of US residence and are compounded by obesity and across generations.

KEYWORDS:

Bacteriodes; Prevotella; immigrant health; immigration; metagenomics; microbiome; microbiota; obesity; refugee health

PMID:
30388453
PMCID:
PMC6498444
DOI:
10.1016/j.cell.2018.10.029
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center