Format

Send to

Choose Destination
Cell Stem Cell. 2018 Nov 1;23(5):653-664. doi: 10.1016/j.stem.2018.10.006.

Orienting Muscle Stem Cells for Regeneration in Homeostasis, Aging, and Disease.

Author information

1
Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
2
Sprott Centre for Stem Cell Research, Regenerative Medicine Program, Ottawa Hospital Research Institute, Ottawa, ON K1H 8L6, Canada; Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada. Electronic address: mrudnicki@ohri.ca.

Abstract

Muscle stem cells, or satellite cells, are required for skeletal muscle maintenance, growth, and repair. Following satellite cell activation, several factors drive asymmetric cell division to generate a stem cell and a proliferative progenitor that forms new muscle. The balance between symmetric self-renewal and asymmetric division significantly impacts the efficiency of regeneration. In this Review, we discuss the relationship of satellite cell heterogeneity and the establishment of polarity to asymmetric division, as well as how these processes are impacted in homeostasis, aging, and disease. We also highlight therapeutic opportunities for targeting satellite cell polarity and self-renewal to stimulate muscle regeneration.

KEYWORDS:

Duchenne muscular dystrophy; PAR complex; aging; asymmetric division; cell polarity; muscle stem cell; regeneration; satellite cell; skeletal muscle; therapy

PMID:
30388423
PMCID:
PMC6262894
[Available on 2019-11-01]
DOI:
10.1016/j.stem.2018.10.006
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center