Format

Send to

Choose Destination
Mol Cell. 2018 Nov 1;72(3):404-412. doi: 10.1016/j.molcel.2018.09.018.

CRISPR-Based Technologies: Impact of RNA-Targeting Systems.

Author information

1
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA 30602, USA; Department of Genetics, University of Georgia, Athens, GA 30602, USA; Department of Microbiology, University of Georgia, Athens, GA 30602, USA. Electronic address: mterns@uga.edu.

Abstract

DNA-targeting CRISPR-Cas systems, such as those employing the RNA-guided Cas9 or Cas12 endonucleases, have revolutionized our ability to predictably edit genomes and control gene expression. Here, I summarize information on RNA-targeting CRISPR-Cas systems and describe recent advances in converting them into powerful and programmable RNA-binding and cleavage tools with a wide range of novel and important biotechnological and biomedical applications.

KEYWORDS:

CRISPR; Cas10; Cas13; Cas9; RNA editing; RNA targeting; Type III CRISPR-Cas systems; Type VI CRISPR-Cas systems; gene editing

PMID:
30388409
PMCID:
PMC6239212
[Available on 2019-11-01]
DOI:
10.1016/j.molcel.2018.09.018
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center