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JNMA J Nepal Med Assoc. 2018 Jul-Aug;56(212):754-758.

Correlates of Biochemical Markers of Bone turnover among Post-Menopausal Women.

Author information

1
Department of Biochemistry, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal.
2
Department of  Internal Medicine, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal.
3
Department of Occupational Health, College of Bio-Medical Sciences, Daegu Catholic University, Gyeongsan 38430, Korea.
4
Department of Anatomy, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal.
5
Department of Internal Medicine, Lumbini Zonal Hospital, Rupandehi, Butwal, Nepal.
6
Department of Orthopedic Surgery, Tilottama Hospital, Rupandehi, Butwal, Nepal.
7
Deapartment of Community Medicine, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal.
8
Department of Preventive Medicine, College of Medicine, Dongguk University, Gyeongju, Republic of Korea,Department of Community Medicine, Devdaha Medical College and Research Institute, Devdaha, Rupandehi, Nepal.

Abstract

INTRODUCTION:

Bone turnover leading to osteoporosis and poor quality of life is common during post-menopausal period. Study of bone turnover markers that contribute to non-invasive assessment of bone-metabolic disorders holds an important area of research in low income country like Nepal. This study aimed to examine the correlates of bone turnover markers in post-menopausal women in tertiary level of health care center of Nepal.

METHODS:

A hospital-based cross-sectional study conducted during the period of November 2016 to December 2017 among 354 women. Blood samples for calcium, inorganic phosphorus, alkaline phosphatase and vitamin D were collected and analyzed using a validated and calibrated tools. Data were analyzed using Statistical Package for the Social Sciences software version 20.

RESULTS:

Mean±Standard deviation of age of post-menopausal women was significantly higher compared to pre-menopausal women (post-menopausal women, (57.98±8.08) vs. pre-menopausal, (31.35±5.83), (P<0.001). Selected biochemical markers of bone-turnover such as alkaline phosphatase levels were significantly higher with year since menopause (P<0.001), whereas serum calcium, and vitamin D were decreasing with year since menopause among post-menopausal women. In addition, calcium and vitamin D were significantly negatively correlated with year since menopause (P<0.01) while body mass index, inorganic phosphorus and alkaline phosphatase were significantly positively correlated with year since menopause (P<0.01).

CONCLUSIONS:

Our study revealed that body mass index, inorganic phosphorus and alkaline phosphatase positively correlated with year since menopause while calcium and vitamin D were negatively correlated suggesting for a medical supervision of hormonal changes and periodic dosing of calcium and vitamin D among post-menopausal women to reduce the problem of bone health.

KEYWORDS:

biochemical markers; bone turnover; osteoporosis; post-menopause.

PMID:
30387463
[Indexed for MEDLINE]

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