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Reprod Biomed Online. 2018 Dec;37(6):685-692. doi: 10.1016/j.rbmo.2018.08.026. Epub 2018 Oct 6.

Assisted reproductive techniques in Latin America: the Latin American Registry, 2015.

Author information

1
Unit of Reproductive Medicine Clínica Las Condes, Lo Fontecilla 441, Santiago, Chile; Program of Ethics and Public Policies in Human Reproduction, University Diego Portales, Ejercito 260, Santiago, Chile; Latin American Network of Assisted Reproduction (REDLARA), Plaza Independencia 811 Montevideo, Uruguay. Electronic address: fzegers@clc.cl.
2
Unit of Reproductive Medicine Clínica Las Condes, Lo Fontecilla 441, Santiago, Chile; Latin American Network of Assisted Reproduction (REDLARA), Plaza Independencia 811 Montevideo, Uruguay.
3
Latin American Network of Assisted Reproduction (REDLARA), Plaza Independencia 811 Montevideo, Uruguay; Unifertes, Av. San Juan Bosco, Caracas, Venezuela.

Abstract

RESEARCH QUESTION:

What was the utilization, effectiveness and safety of assisted reproductive technologies (ART) performed in Latin American countries during 2015, and what were the regional trends?

DESIGN:

Retrospective collection of multinational data on assisted reproduction techniques (IVF and intracytoplasmic sperm injection [ICSI], frozen embryo transfer, oocyte donation, preimplantation genetic testing and fertility preservation), from 175 institutions in 15 Latin American countries.

RESULTS:

In total, 41.25% of IVF/ICSI cycles were performed in women aged 35-39 years, and 28.35% in women aged ≥40 years. After removing freeze-all cycles, delivery rate per oocyte retrieval was 21.39% for ICSI and 24.29% for IVF. Multiple births included 19.58% twins and 0.95% triplets and higher. In oocyte donation, delivery rate per transfer was 36.77%, with a twin and triplet rate of 27.65% and 1.06%, respectively. Overall, preterm deliveries reached 17.38% in singletons, 64.94% in twins and 98.41% in triplets. Perinatal mortality in 14,936 births and 18,391 babies born was 10.5 per 1000 in singletons, 17.9 per 1000 in twins, and 57.1 per 1000 in high-order multiples. Elective single embryo transfer represented 3.11% of fresh transfers, with a 31.78% delivery rate per transfer. Elective double embryo transfer represented 23.3% of transfers, with a 37.79% delivery rate per transfer. Out of 18,391 babies born, 63.22% were singletons, 34.4% twins, and 2.38% triplets and higher.

CONCLUSIONS:

Given the effect of multiple births on prematurity, morbidity and perinatal mortality, reinforcing the existing trend of reducing the number of embryos transferred remains mandatory.

KEYWORDS:

ART; Assisted reproductive technologies; Multiple pregnancy; Outcome; Registry

PMID:
30385145
DOI:
10.1016/j.rbmo.2018.08.026

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