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Genes (Basel). 2018 Oct 31;9(11). pii: E529. doi: 10.3390/genes9110529.

Aptamer Chimeras for Therapeutic Delivery: The Challenging Perspectives.

Author information

1
Istituto di Endocrinologia ed Oncologia Sperimentale "G. Salvatore", Consiglio Nazionale delle Ricerche (CNR), 80145 Naples, Italy. c.esposito@ieos.cnr.it.
2
Istituto di Endocrinologia ed Oncologia Sperimentale "G. Salvatore", Consiglio Nazionale delle Ricerche (CNR), 80145 Naples, Italy. s.catuogno@ieos.cnr.it.
3
Department of Molecular Medicine and Medical Biotechnology, "Federico II" University of Naples, 80145 Naples, Italy. gecondor@unina.it.
4
Istituto di Endocrinologia ed Oncologia Sperimentale "G. Salvatore", Consiglio Nazionale delle Ricerche (CNR), 80145 Naples, Italy. pungaro@ieos.cnr.it.
5
Istituto di Endocrinologia ed Oncologia Sperimentale "G. Salvatore", Consiglio Nazionale delle Ricerche (CNR), 80145 Naples, Italy. defranci@unina.it.

Abstract

Nucleic acid-based aptamers have emerged as efficient delivery carriers of therapeutics. Thanks to their unique features, they can be, to date, considered one of the best targeting moieties, allowing the specific recognition of diseased cells and avoiding unwanted off-target effects on healthy tissues. In this review, we revise the most recent contributes on bispecific and multifunctional aptamer therapeutic chimeras. We will discuss key examples of aptamer-mediated delivery of nucleic acid and peptide-based therapeutics underlying their great potentiality and versatility. Achieved objectives and challenges will be highlighted as well.

KEYWORDS:

aptamer; chimeras; targeted delivery

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