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Medicine (Baltimore). 2018 Nov;97(44):e13049. doi: 10.1097/MD.0000000000013049.

Comparison of platelet-rich plasma vs hyaluronic acid injections in patients with knee osteoarthritis: A protocol for a systematic review and meta-analysis.

Author information

1
Second School of Clinical Medicine, Guangzhou University of Chinese Medicine.
2
Department of Orthopedics, Second Affiliated Hospital of the Guangzhou University of Chinese Medicine, Guangdong Provincial Hospital of Chinese Medicine.
3
Bone and Joint Research Team of Degeneration and Injury, Guangdong Provincial Academy of Chinese Medical Sciences, Guangzhou, China.

Abstract

BACKGROUND:

Knee osteoarthritis (KOA) is a progressive joint disease involving intraarticular and periarticular structures. In recent years, there has been increasing interest in the use of autologous growth factors, such as intraarticular injections of platelet-rich plasma (PRP), to treat KOA. It is necessary to update the research and reevaluate the efficacy and safety of PRP to provide up-to-date evidence for KOA management. Therefore, we provide a protocol for a systematic review of PRP for KOA.

METHODS:

The aim of this study was to retrieve papers on the topic of PRP treatment for KOA in electronic databases including PubMed, Embase, and the Cochrane Library. The search will include studies that were published from the time the databases were established until April 2018. The entire process will include study selection, data extraction, risk of bias assessment, and meta-analyses.

RESULTS:

The literature will provide a high-quality analysis of the current evidence supporting PRP for KOA based on various comprehensive assessments including the Western Ontario and McMaster Universities Osteoarthritis Index, visual analog scale scores, International Knee Documentation Committee scores, Lequesne index scores, and adverse events.

CONCLUSION:

This proposed systematic review will provide up-to-date evidence to assess the effect of PRP treatment for patients with KOA.

PROSPERO REGISTRATION NUMBER:

CRD42018108825.

PMID:
30383675
PMCID:
PMC6221718
DOI:
10.1097/MD.0000000000013049
[Indexed for MEDLINE]
Free PMC Article

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