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J Autism Dev Disord. 2018 Oct 31. doi: 10.1007/s10803-018-3796-2. [Epub ahead of print]

ASD Comorbidity in Fragile X Syndrome: Symptom Profile and Predictors of Symptom Severity in Adolescent and Young Adult Males.

Author information

1
University of California, Davis, USA. LJabebduto@ucdavis.edu.
2
UC Davis MIND Institute, 2825 50th St, Sacramento, CA, 95817, USA. LJabebduto@ucdavis.edu.
3
University of California, Davis, USA.
4
University of South Carolina, Columbia, USA.
5
New York State Institute for Basic Research in Developmental Disabilities, New York, USA.

Abstract

Many males with FXS meet criteria for ASD. This study was designed to (1) describe ASD symptoms in adolescent and young adult males with FXS (nā€‰=ā€‰44) and (2) evaluate the contributions to ASD severity of cognitive, language, and psychiatric factors, as well as FMRP (the protein deficient in FXS). A few ASD symptoms on the ADOS-2 were universal in the sample. There was less impairment in restricted and repetitive behaviors (RRB) than in the social affective (SA) domain. The best predictor of overall ASD severity and SA severity was expressive syntactic ability. RRB severity was best predicted by the psychiatric factors. Implications for clinical practice and for understanding the ASD comorbidity in FXS are discussed.

KEYWORDS:

Autism spectrum disorder; FMRP; Fragile X syndrome; IQ; Language; Psychiatric symptoms

PMID:
30382442
DOI:
10.1007/s10803-018-3796-2

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