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Methods Mol Biol. 2019;1882:309-320. doi: 10.1007/978-1-4939-8879-2_27.

Orthotopic Pancreatic Tumor Mouse Models of Liver Metastasis.

Author information

1
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA.
2
Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA. nad2012@med.cornell.edu.

Abstract

The survival from pancreatic cancer is poor because most patients are diagnosed after the cancer has metastasized. Liver is the most common site of pancreatic cancer metastasis. Orthotopic mouse models of liver metastasis by intrasplenically injecting the pancreatic tumor cells are useful in studying the molecular mechanisms of metastasis and evaluating therapeutic regimens.

KEYWORDS:

Intrasplenic injection; Liver; Metastasis; Mouse model; Orthotopic; Pancreatic cancer; Splenectomy

PMID:
30378065
DOI:
10.1007/978-1-4939-8879-2_27
[Indexed for MEDLINE]

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