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Rev Med Inst Mex Seguro Soc. 2018 Oct 25;56(3):246-254.

Obesity and adipocytokines in breast cancer and benign breast disease

[Article in Spanish; Abstract available in Spanish from the publisher]

Abstract

in English, Spanish

Background:

There is a relationship between obesity and the development of breast cancer; adipocytokines are among the mechanisms related.

Objective:

To describe the impact of obesity in leptin, adiponectin, resistin and tumor necrosis factor-alpha (TNF-alpha) serum levels in women with breast cancer (BC) and benign breast disease (BBD).

Methods:

A cross-sectional study was carried out with a sample of 54 individuals divided into two groups: BC (n = 27) and BBD (n = 27). Serum levels of leptin, adiponectin, resistin and TNF-alpha were determined. Body mass index (BMI) was calculated. Statistical analysis included mean, standard deviation, median and interquartile range; the differences between groups were determined by Student´s t test, Mann-Whitney U and Kruskall Wallis test to identify differences between the groups.

Results:

We didn’t find any significant differences related to anthropometric characteristics between BC and BBD groups, or to leptin, adiponectin, resistin and TNF-alpha serum levels (p = NS). We found higher leptin serum levels in obese women with BBD compared with non-obese women with BC (med 22.26 versus 4.34 ng/mL; p = 0.028). Adiponectin serum levels in non-obese women from the BC group were higher than serum levels found in non-obese women with BBD (med 7.10 versus 2.22 ng/mL; p = 0.038)

Conclusion:

We found higher leptin serum levels and lower adiponectin serum levels in BBD women than BC women in this population with high frequency of obesity.

KEYWORDS:

Obesity; Leptin; Adiponectin; Breast Neoplasms

PMID:
30376276
[Indexed for MEDLINE]

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