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J Cereb Blood Flow Metab. 2019 Feb;39(2):367-370. doi: 10.1177/0271678X18811277. Epub 2018 Oct 30.

May the force be with you: Transfer of healthy mitochondria from stem cells to stroke cells.

Author information

1
1 Department of Neurosurgery and Brain Repair, College of Medicine, University of South Florida Morsani, Tampa, FL, USA.
2
2 Department of Molecular Biosciences, University of California Davis, Davis, CA, USA.

Abstract

Stroke is a major cause of death and disability in the United States and around the world with limited therapeutic option. Here, we discuss the critical role of mitochondria in stem cell-mediated rescue of stroke brain by highlighting the concept that deleting the mitochondria from stem cells abolishes the cells' regenerative potency. The application of innovative approaches entailing generation of mitochondria-voided stem cells as well as pharmacological inhibition of mitochondrial function may elucidate the mechanism underlying transfer of healthy mitochondria to ischemic cells, thereby providing key insights in the pathology and treatment of stroke and other brain disorders plagued with mitochondrial dysfunctions.

KEYWORDS:

Cerebral ischemia; cellular bioenergetics; energy metabolism; inflammation; regenerative medicine; transplantation

PMID:
30375940
PMCID:
PMC6365599
DOI:
10.1177/0271678X18811277

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