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Transcription. 2018 Oct 30:1-7. doi: 10.1080/21541264.2018.1530936. [Epub ahead of print]

Share and share alike: the role of Tra1 from the SAGA and NuA4 coactivator complexes.

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a Department of Structural and Molecular Biology , University College London, Institute of Structural and Molecular Biology , London , UK.
b Institute of Structural and Molecular Biology, Biological Sciences , Birkbeck College , London , UK.


SAGA and NuA4 are coactivator complexes required for transcription on chromatin. Although they contain different enzymatic and biochemical activities, both contain the large Tra1 subunit. Recent electron microscopy studies have resolved the complete structure of Tra1 and its integration in SAGA/NuA4, providing important insight into Tra1 function.


Chromatin and transcription; Eukaryotic transcription; NuA4; SAGA; Tra1; Transcription factors and co-activators; activator; coactivator; histone acetylation

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