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ACS Nano. 2018 Nov 27;12(11):11355-11365. doi: 10.1021/acsnano.8b06201. Epub 2018 Nov 5.

Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors.

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CAS Key Laboratory of Magnetic Materials and Devices, & Key Laboratory of Additive Manufacturing Materials of Zhejiang Province, & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering , Chinese Academy of Sciences , 1219 Zhong-guan West Road , Ningbo , Zhejiang 315201 , China.
Laboratory of Molecular Imaging and Nanomedicine , National Institute of Biomedical Imaging and Bioengineering , National Institutes of Health, Bethesda , Maryland 20892 , United States.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health , Xiamen University , Xiamen 361102 , China.
College of Food and Pharmaceutical Sciences , Ningbo University , Ningbo 315211 , China.
A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences , Vavilov Str. 28 , Moscow 119991 , Russia.
Department of Chemical Sciences , Indian Institute of Science Education and Research-Kolkata , Mohanpur 741246 , India.
Department of Pharmaceutics, School of Pharmacy, Massey Cancer Center , Virginia Commonwealth University , Richmond , Virginia 23298-0533 , United States.
Mouse Imaging Facility , National Institute of Neurological Disorder and Stroke , National Institutes of Health, Bethesda , Maryland 20892 , United States.


Cancer is one of the leading causes of morbidity and mortality in the world, but more cancer therapies are needed to complement existing regimens due to problems of existing cancer therapies. Herein, we term ferroptosis therapy (FT) as a form of cancer therapy and hypothesize that the FT efficacy can be significantly improved via accelerating the Fenton reaction by simultaneously increasing the local concentrations of all reactants (Fe2+, Fe3+, and H2O2) in cancer cells. Thus, Fenton-reaction-acceleratable magnetic nanoparticles, i.e., cisplatin (CDDP)-loaded Fe3O4/Gd2O3 hybrid nanoparticles with conjugation of lactoferrin (LF) and RGD dimer (RGD2) (FeGd-HN@Pt@LF/RGD2), were exploited in this study for FT of orthotopic brain tumors. FeGd-HN@Pt@LF/RGD2 nanoparticles were able to cross the blood-brain barrier because of its small size (6.6 nm) and LF-receptor-mediated transcytosis. FeGd-HN@Pt@LF/RGD2 can be internalized into cancer cells by integrin αvβ3-mediated endocytosis and then release Fe2+, Fe3+, and CDDP upon endosomal uptake and degradation. Fe2+ and Fe3+ can directly participate in the Fenton reaction, whereas the CDDP can indirectly produce H2O2 to further accelerate the Fenton reaction. The acceleration of Fenton reaction generates reactive oxygen species to induce cancer cell death. FeGd-HN@Pt@LF/RGD2 successfully delivered reactants involved in the Fenton reaction to the tumor site and led to significant inhibition of tumor growth. Finally, the intrinsic magnetic resonance imaging (MRI) capability of the nanoparticles was used to assess and monitor tumor response to FT (self-MRI monitoring).


Fenton reaction; ferroptosis therapy; magnetic nanoparticles; orthotopic glioblastoma; self-MRI monitoring


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