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Lung. 2018 Oct 29. doi: 10.1007/s00408-018-0173-z. [Epub ahead of print]

Thoracic Air-Leak Syndrome Complicating Allogeneic Hematopoietic Stem-Cell Transplantation.

Author information

1
Pôle des Voies Respiratoires, Hôpital Larrey, CHU de Toulouse, 31059, Toulouse Cedex 09, France.
2
Service d'hématologie, CHU Toulouse, Toulouse, France.
3
Hôpital Pasteur and Institute for Research on Cancer and Ageing (IRCAN) (Inserm U10181/UMR CNRS 7284), University Nice Sophia Antipolis, Nice, France.
4
Pôle des Voies Respiratoires, Hôpital Larrey, CHU de Toulouse, 31059, Toulouse Cedex 09, France. didier.a@chu-toulouse.fr.

Abstract

We report a case of thoracic air-leak syndrome, an extremely rare complication developed after an episode of organizing pneumonia due to graft-vs-host disease in a 19-year-old male. This unusual non-infectious pulmonary complication occurred 527 days after allogeneic HSCT and led to the patient's death within 1 month due to cardio-respiratory failure. Herein, we highlight chest-imaging aspects which are typical. Early detection by high-resolution chest CT could improve patient management.

KEYWORDS:

Air-leak; Allogeneic hematopoietic stem-cell transplantation; Graft-versus-host disease; Pneumomediastinum; Pneumothorax

PMID:
30374588
DOI:
10.1007/s00408-018-0173-z

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