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Nat Struct Mol Biol. 2018 Nov;25(11):1009-1018. doi: 10.1038/s41594-018-0148-z. Epub 2018 Oct 29.

Organellar TRP channels.

Author information

1
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
2
Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou, China.
3
Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. haoxingx@umich.edu.

Abstract

Mammalian transient receptor potential (TRP) channels mediate Ca2+ flux and voltage changes across membranes in response to environmental and cellular signals. At the plasma membrane, sensory TRPs act as neuronal detectors of physical and chemical environmental signals, and receptor-operated (metabotropic) TRPs decode extracellular neuroendocrine cues to control body homeostasis. In intracellular membranes, such as those in lysosomes, organellar TRPs respond to compartment-derived signals to control membrane trafficking, signal transduction, and organelle function. Complementing mouse and human genetics and high-resolution structural approaches, physiological studies employing natural agonists and synthetic inhibitors have become critical in resolving the in vivo functions of metabotropic, sensory, and organellar TRPs.

PMID:
30374082
PMCID:
PMC6785982
DOI:
10.1038/s41594-018-0148-z
[Indexed for MEDLINE]
Free PMC Article

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