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J Cancer Prev. 2018 Sep;23(3):126-133. doi: 10.15430/JCP.2018.23.3.126. Epub 2018 Sep 30.

Application of the Adverse Outcome Pathway Framework to Risk Assessment for Predicting Carcinogenicity of Chemicals.

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Institute of Environmental Medicine for Green Chemistry, Department of Life Science, Dongguk University Biomedi Campus, Goyang, Korea.
Department of Chemical and Biological Engineering, College of Natural Science and Engineering, Seokyeong University, Seoul, Korea.
Department of Preventive Medicine and Institute of Occupational and Environmental Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Faculty of Health Science, Daegu Haany University, Gyeongsan, Korea.


As industry develops in modern society, many chemicals are being used. The safety of chemicals is an important issue because humans are constantly exposed to chemicals throughout their daily life. Through a risk assessment, the hazardous human effects of chemicals can be identified. Recently, the adverse outcome pathway (AOP) framework has been used to predict the adverse effects of chemicals. As a conceptual framework for organizing existing biological knowledge, the AOP consists of a molecular initiating event, key events, and an adverse outcome. These independent elements represent biological responses and are connected by key event relationships. This AOP framework provides intuitive hazard identification that can be helpful for carcinogenic risk assessment of chemicals. In this review, we introduce the application of the AOP framework to risk assessment for predicting carcinogenicity of chemicals and illustrate the utility of this approach for cancer prevention.


Adverse outcome pathways; Carcinogenesis; Chemical safety; Risk assessment

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CONFLICTS OF INTEREST No potential conflicts of interest were disclosed.

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