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Sex Transm Dis. 2019 Apr;46(4):e42-e45. doi: 10.1097/OLQ.0000000000000935.

Increased Discrimination of Treponema pallidum Strains by Subtyping With a 4-Component System Incorporating a Mononucleotide Tandem Repeat in rpsA.

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British Columbia Centre for Disease Control Public Health Laboratory, Vancouver, Canada.
Lawrence Livermore National Laboratory, Livermore, CA.
San Francisco Department of Public Health, San Francisco, CA.
Center for Global Health, Centers for Disease Control and Prevention, Atlanta, GA.


A guanine mononucleotide repeat in the rpsA (tp0279) gene was evaluated for improved strain discrimination using 72 Treponema pallidum-positive specimens. The tandem repeat combined with the enhanced Centers for Disease Control and Prevention typing system resulted in increased discrimination and should be useful for molecular epidemiologic studies on syphilis especially in outbreaks and among men who have sex with men.

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