Format

Send to

Choose Destination
Pediatr Emerg Care. 2018 Oct 25. doi: 10.1097/PEC.0000000000001595. [Epub ahead of print]

Topical Ketoprofen Versus Placebo in Children Presenting With Ankle Sprain to the Emergency Department: A Randomized Controlled Study.

Author information

1
Department of Emergency Medicine, Akdeniz University Medical Faculty, Antalya.
2
Department of Emergency Medicine, Kocatepe University Medical Faculty, Afyonkarahisar.
3
Department of Emergency Medicine, Manisa Celal Bayar University Medical Faculty, Manisa, Turkey.

Abstract

OBJECTIVE:

Despite the favorable data concerning topical agents use in outpatient clinics, they are not commonly in emergency departments (EDs). The present study aimed to compare the effect of 2.5% topical ketoprofen (gel form) to placebo in children presenting with ankle sprain to the ED.

STUDY DESIGN:

Children between 7 and 18 years old presenting with ankle sprain composed the study population. Study patients were randomized into 2 study arms: 2.5% ketoprofen gel and placebo administered in a 5-cm area locally. Pain improvements at 15 and 30 minutes were measured by visual analog scale.

RESULTS:

Median pain reductions at 15 minutes for ketoprofen and placebo groups were 27.5 (16-39) and 5 (4-10), respectively. Median changes in pain intensity at 30 minutes for ketoprofen and placebo gel groups were 48 (43-52) and 9 (6-16), respectively. When compared 2 arms for the pain improvement at 15 and 30 minutes, the differences between 2 study drugs were 20 (13-28) and 35 (29-41), respectively. There were 7 (12.7%) rescue drug needs in the placebo group and 1 (1.7%) in the ketoprofen group (difference, 10.9%; 95% confidence interval, -6% to 7%; P = 0.83). There were no adverse effects in either group.

CONCLUSIONS:

Ketoprofen gel is superior to placebo in ceasing pain in children presenting with ankle sprain to the ED with a high safety profile.

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center