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Nucleic Acids Res. 2019 Jan 8;47(D1):D983-D988. doi: 10.1093/nar/gky1027.

EWAS Atlas: a curated knowledgebase of epigenome-wide association studies.

Li M1,2,3, Zou D1,2, Li Z1,2,4, Gao R3,5, Sang J1,2,3, Zhang Y1,2,3, Li R1,2, Xia L1,2,3, Zhang T1,2,3, Niu G1,2,3, Bao Y1,2,3,4, Zhang Z1,2,3,5.

Author information

1
BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
2
CAS Key Laboratory of Genome Sciences and Information, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.
3
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China.
4
School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, China.
5
CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.

Abstract

Epigenome-Wide Association Study (EWAS) has become increasingly significant in identifying the associations between epigenetic variations and different biological traits. In this study, we develop EWAS Atlas (http://bigd.big.ac.cn/ewas), a curated knowledgebase of EWAS that provides a comprehensive collection of EWAS knowledge. Unlike extant data-oriented epigenetic resources, EWAS Atlas features manual curation of EWAS knowledge from extensive publications. In the current implementation, EWAS Atlas focuses on DNA methylation-one of the key epigenetic marks; it integrates a large number of 329 172 high-quality EWAS associations, involving 112 tissues/cell lines and covering 305 traits, 1830 cohorts and 390 ontology entities, which are completely based on manual curation from 649 studies reported in 401 publications. In addition, it is equipped with a powerful trait enrichment analysis tool, which is capable of profiling trait-trait and trait-epigenome relationships. Future developments include regular curation of recent EWAS publications, incorporation of more epigenetic marks and possible integration of EWAS with GWAS. Collectively, EWAS Atlas is dedicated to the curation, integration and standardization of EWAS knowledge and has the great potential to help researchers dissect molecular mechanisms of epigenetic modifications associated with biological traits.

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