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J Vet Res. 2018 Oct 24;62(2):229-235. doi: 10.2478/jvetres-2018-0020. eCollection 2018 Jun.

Increased p63 Expression in Canine Perianal Gland Tumours.

Author information

1
Small Animal Tumour Diagnostic Centre, Department of Veterinary Pathology, Konkuk University, 05029, Seoul, Republic of Korea.
2
Department of Veterinary Internal Medicine, College of Veterinary Medicine, Konkuk University, 05029, Seoul, Republic of Korea.

Abstract

Introduction:

p63 is a homologous molecule of p53 and was recently identified as playing important roles in several key cellular processes, including epithelial development and proliferation. Since then, several studies have demonstrated altered p63 expression in various cancers of epithelial origin. Canine perianal gland tumour is one of the most common skin neoplasms in dogs; however, the molecular characteristics of this tumour remain poorly understood. The objective of the present study was to analyse and compare the expression of p63 in canine perianal gland adenomas and carcinomas.

Material and Methods:

Haematoxylin and eosin-stained slides were examined and immunohistochemistry was conducted for a total of 65 samples. Immunohistochemical data for p63 expressions were compared between groups using the Mann-Whitney U test.

Results:

The p63 expression level was increased in perianal gland carcinomas compared to that in the adenoma samples (P < 0.0001). The percentage of cells expressing p63 was higher in perianal gland carcinomas than in adenomas, although the intensity of immunostaining did not differ significantly between the two groups.

Conclusion:

p63 is a candidate factor contributing to the malignant transformation and progression of canine perianal gland tumours.

KEYWORDS:

dog; immunohistochemistry; p63; perianal gland tumour

Conflict of interest statement

Conflict of Interests Statement The authors declare that there is no conflict of interests regarding the publication of this article.

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