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F1000Res. 2018 Oct 11;7. pii: F1000 Faculty Rev-1631. doi: 10.12688/f1000research.15849.1. eCollection 2018.

Recent advances in understanding non-celiac gluten sensitivity.

Author information

1
Department of Medical and Surgical Sciences (DIMEC) and Center for Applied Biomedical Research (CRBA), Alma Mater Studiorum - University of Bologna and S. Orsola-Malpighi Hospital, Bologna, Italy.

Abstract

Non-celiac gluten sensitivity (NCGS) is a condition characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing foods in the absence of celiac disease and wheat allergy. The diagnosis is cumbersome and currently confirmed only by gluten withdrawal and double-blind placebo challenge protocols. There is great overlap in symptoms between NCGS and other functional gastrointestinal disorders, making a differential diagnosis difficult. The pathophysiology of NCGS is largely unclear, and there are contrasting data on the trigger of this condition. This review will highlight the state-of-the-art knowledge on NCGS and the key open questions.

KEYWORDS:

IBS; NCGS; diagnosis; gluten; wheat

PMID:
30363819
PMCID:
PMC6182669
DOI:
10.12688/f1000research.15849.1
[Indexed for MEDLINE]
Free PMC Article

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