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Scand J Urol. 2018 Oct 26:1-8. doi: 10.1080/21681805.2018.1512650. [Epub ahead of print]

Work-up and treatment of prostate cancer before and after publication of the first national guidelines on prostate cancer care in Sweden.

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a Department of Surgery , Falun Hospital , Falun , Sweden.
b Regional Cancer Center Uppsala Örebro , Uppsala University Hospital , Uppsala , Sweden.
c Department of Urology, Institute of Clinical Sciences , Sahlgrenska Academy at the University of Gothenburg, Sahlgrenska University Hospital , Göteborg , Sweden.
d Department of Clinical Science, Intervention and Technology , Karolinska Institute , Stockholm , Sweden.
e Department of Urology , Ryhov Hospital , Jönköping , Sweden.
f Department of Surgical Sciences , Uppsala University , Uppsala , Sweden.



In 2007, the Swedish National Board of Health and Welfare published the first Swedish guidelines on prostate cancer (PCa) to improve care and decrease geographical and social inequalities. The aim of this analysis was to assess how these guidelines affected PCa care.


Work-up and treatment for men diagnosed with PCa between 1998 and 2014 were assessed by use of data in the Prostate Cancer data Base Sweden (PCBaSe) with information from the National Prostate Cancer Register (NPCR) and other healthcare registries and demographic databases.


Overall, there were modest improvements in the performance for 14 selected quality indicators, with some notable exceptions. There was a strong increase in the use of active surveillance for very low-risk PCa, up from 56% in 2009 to 92% in 2014, and use of bone imaging for high-risk PCa up from 50% in 2008 to 77% in 2014. There were large differences in work-up and treatment of PCa between healthcare providers with modest decreases over time. The differences between counties were larger than differences according to socioeconomic status with one exception: use of curative treatment for high-risk PCa was more common in men with high income, highest versus lowest tertile, OR 2.74 (95% CI, 1.85-4.06).


The modest improvements in PCa care after the publications of national guidelines indicate that if these are to make an impact on care, feedback to each point of care on their performance as well as local quality improvement programs implementing the guidelines are needed.


Prostate cancer; cancer guidelines; cancer registries; quality indicators; socio-economical differences

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