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Curr Drug Targets. 2019;20(4):453-464. doi: 10.2174/1389450119666181026152221.

CDK9 as an Appealing Target for Therapeutic Interventions.

Author information

1
Molecular Medicine Research Center, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.
2
Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
3
Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
4
Department of Molecular Medicine, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
5
Faculty of medicine, Tabriz University of Medical Sciences, Tabriz, Iran.

Abstract

Cyclin Dependent Kinase 9 (CDK9) as a serine/threonine kinase belongs to a great number of CDKs. CDK9 is the main core of PTEF-b complex and phosphorylates RNA polymerase (RNAP) II besides other transcription factors which regulate gene transcription elongation in numerous physiological processes. Multi-functional nature of CDK9 in diverse cellular pathways proposes that it is as an appealing target. In this review, we summarized the recent findings on the molecular interaction of CDK9 with critical participant molecules to modulate their activity in various diseases. Furthermore, the presented review provides a rationale supporting the use of CDK9 as a therapeutic target in clinical developments for crucial diseases; particularly cancers will be reviewed.

KEYWORDS:

CDK9; RNAP; cancer; cardiac pathway; fibrosis; inflammation; viral agents.

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