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Enzymes. 2018;44:35-59. doi: 10.1016/bs.enz.2018.08.001. Epub 2018 Oct 5.

Drug Delivery and Bone Infection.

Author information

1
Department of Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense de Madrid and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain. Electronic address: vallet@ucm.es.
2
Department of Chemistry in Pharmaceutical Sciences, School of Pharmacy, Universidad Complutense de Madrid and Networking Research Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain.

Abstract

Bone infection represents greatest challenge in public health care with serious social and economic implications. The efforts of the scientific community are focused in the development of innovative and advanced biomaterials with anti-infective properties related to their non-fouling, bactericidal and/or antibiofilm capabilities. This chapter aims at thoroughly surveying the different approaches based on silica mesoporous materials (SMMs) for bone infection management. Bacteria repelling surfaces by zwitterionization process, bactericidal effect by implantable devices with antimicrobial local delivery agents and antibiofilm effect by more sophisticated systems based on targeted nanocarriers will be considered.

KEYWORDS:

Bacteria targeting; Bacterial adhesion inhibition; Biocompatibility; Biofilm targeting; Drug delivery mesoporous materials; Hierarchical 3D meso-macro scaffolds; Mesoporous silica nanoparticles; Non-fouling properties; Preventing and treatment of bone infection; Targeting therapy; Zwitterionic mesoporous materials

PMID:
30360814
DOI:
10.1016/bs.enz.2018.08.001
[Indexed for MEDLINE]

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