Preserved endothelial function in young adults with type 1 diabetes

PLoS One. 2018 Oct 25;13(10):e0206523. doi: 10.1371/journal.pone.0206523. eCollection 2018.

Abstract

Background and aim: Endothelial dysfunction is involved in the pathogenesis of atherosclerosis and is typically present in older adults with type 1 diabetes (T1D). In young adults, we aimed to assess the impact of T1D on endothelial function as detected by digital peripheral arterial tonometry (PAT) and its relationship with cardiovascular risk factors and long term glycemic control.

Materials and methods: Reactive hyperemia index (RHI) as a measure of endothelial function was assessed by PAT in 46 T1D patients and 32 healthy controls. All were participants in the "Atherosclerosis and Childhood Diabetes" study, with baseline values registered five years previously. Annual measurements of HbA1c for assessment of glycemic burden were provided by the Norwegian Childhood Diabetes Registry.

Results: The diabetes patients had a mean age of 20.8 years, a median duration of diabetes of 10.0 years and a mean HbA1c of 8.7%. RHI was not significantly decreased in the diabetes group, mean 2.00 (SD = 0.59) vs. 2.21 (SD = 0.56), p = .116. There was no gender difference or any associations with traditional risk factors. Furthermore, there was no significant association between RHI and either HbA1c or long term glycemic burden.

Conclusions: RHI as a measure of endothelial function was preserved in young adults with T1D compared with healthy controls.

Publication types

  • Research Support, Non-U.S. Gov't

Grants and funding

The Norwegian Extra Foundation for Health and Rehabilitation funded HDM to initiate the “Atherosclerosis and Childhood Diabetes” study. https://www.extrastiftelsen.no The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.