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J Craniofac Surg. 2018 Oct 24. doi: 10.1097/SCS.0000000000004862. [Epub ahead of print]

In Vitro Effect of Bromelain on the Regenerative Properties of Mesenchymal Stem Cells.

Author information

1
Centre for Integrative Biology (CIBIO), University of Trento, Trento.
2
Institute for Dental and Implant Studies (IDIS).
3
Department of Neurosciences, University of Padova, Padova.
4
Department of Biomedical and Neuromotorial Science, University of Bologna, Bologna.
5
Private Practice, Merano.
6
Department of Biomedical Sciences, University of Padova, Padova.
7
Department of Health Sciences, "A. Avogadro" University of Eastern Piedmont, Novara.
8
Maria Cecilia Hospital, GVM Care and Research, Cotignola (RA), Italy.

Abstract

BACKGROUND:

Bromelain belongs to a group of protein-digesting enzymes obtained commercially from the fruit or stem of pineapple. Several studies demonstrated that bromelain exhibits various fibrinolytic, anti-edematous, antithrombotic, and anti-inflammatory activities supporting its application for many therapeutic benefits. The aim of this study was to analyze the effects of bromelain on the pro-wound healing activities and the regenerative properties of mesenchymal stem cells.

METHODS:

Mesenchymal stem cells were treated in vitro with bromelain alone or combined with dexamethasone sodium phosphate. Real-time polymerase chain reaction was performed to profile the expression of extracellular matrix components and remodeling enzymes, and cytokines.

RESULTS:

The combination of bromelain and dexamethasone sodium phosphate induced a great activation of mesenchymal stem cells with an increase in hyaluronan and collagen production and anti-inflammatory cytokines release.

CONCLUSION:

Based on the results of this in vitro study, the combined use of bromelain and dexamethasone sodium phosphate stimulated the pro-wound healing activities and the regenerative properties of mesenchymal stem cells better than bromelain and dexamethasone alone.

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