Format

Send to

Choose Destination
J Med Primatol. 2019 Feb;48(1):10-21. doi: 10.1111/jmp.12374. Epub 2018 Oct 25.

Characterization of glucose-stimulated insulin release protocols in african green monkeys (Chlorocebus aethiops).

Author information

1
RxGen Inc., New Haven, Connecticut.
2
St. Kitts Biomedical Research Foundation, Basseterre, St. Kitts W.I.
3
Regeneron Pharmaceuticals Inc., Tarrytown, New York.

Abstract

BACKGROUND:

Management of diabetes remains a major health and economic challenge, demanding test systems in which to develop new therapies. These studies assessed different methodologies for determining glucose tolerance in green monkeys.

METHODS:

Twenty-eight African green monkeys between 4 and 24 years old underwent single or repeat intravenous glucose tolerance testing (IVGTT), oral glucose tolerance testing (OGTT), and/or graded glucose infusion testing.

RESULTS:

Geriatric monkeys exhibited glucose intolerance with impaired glucose-stimulated insulin secretion following IVGTT. Repeat IVGTT and OGTT assessments were inconsistent. Monkeys with low glucose-stimulated insulin secretion after graded glucose infusion exhibited elevated blood glucose levels.

CONCLUSION:

IVGTT and graded glucose infusion protocols revealed differences in glucose tolerance among green monkeys at single time points, including age-dependent differences suggestive of shifts in pancreatic beta-cell functional capacity, but care should be applied to study design and the interpretation of data in the setting of longitudinal studies.

KEYWORDS:

African green monkey; aging; diabetes; graded glucose infusion; insulinopenic; intravenous glucose tolerance test; nonhuman primates; oral glucose tolerance test; plasma insulin; vervet

Supplemental Content

Full text links

Icon for Wiley Icon for PubMed Central
Loading ...
Support Center