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Adv Exp Med Biol. 2018;1077:371-387. doi: 10.1007/978-981-13-0947-2_20.

Silk Fibroin-Based Scaffold for Bone Tissue Engineering.

Author information

1
Department of BIN Convergence Technology, Chonbuk National University, Jeonju-si, Jeollabuk-do, South Korea.
2
Department of PolymerNano Science & Technology and Polymer Fusion Research Center, Chonbuk National University, Jeonju-si, Jeollabuk-do, South Korea.
3
ICVS/3B's - PT Government Associated Laboratory, Braga/Guimarães, Portugal.
4
The Discoveries Centre for Regenerative and Precision Medicine, Headquarters at University of Minho, Avepark, Guimarães, Portugal.
5
Department of BIN Convergence Technology, Chonbuk National University, Jeonju-si, Jeollabuk-do, South Korea. gskhang@jbnu.ac.kr.

Abstract

Regeneration of diseased or damaged skeletal tissues is one of the challenge that needs to be solved. Although there have been many bone tissue engineering developed, scaffold-based tissue engineering complement the conventional treatment for large bone by completing biological and functional environment. Among many materials, silk fibroin (SF) is one of the favorable material for applications in bone tissue engineering scaffolding. SF is a fibrous protein mainly extracted from Bombyx mori. and spiders. SF has been used as a biomaterial for bone graft by its unique mechanical properties, controllable biodegradation rate and high biocompatibility. Moreover, SF can be processed using conventional and advanced biofabrication methods to form various scaffold types such as sponges, mats, hydrogels and films. This review discusses about recent application and advancement of SF as a biomaterial.

KEYWORDS:

Biomaterial; Bone regeneration; Bone tissue engineering; Scaffold; Silk fibroin; Tissue engineering

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