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J Infect Dis. 2018 Oct 24. doi: 10.1093/infdis/jiy573. [Epub ahead of print]

Rotavirus Vaccine Take in Infants Is Associated With Secretor Status.

Author information

1
Noguchi Memorial Institute for Medical Research, University of Ghana, Legon.
2
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
3
Department of Pediatrics, Perinatal Institute, Ohio.
4
Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center, Ohio.
5
PPD, San Diego, California, USA.
6
Navrongo Health Research Centre, Ministry of Health, Ghana.

Abstract

Rotaviruses bind to enterocytes in a genotype-specific manner via histo-blood group antigens (HBGAs), which are also detectable in saliva. We evaluated antirotavirus immunoglobulin A seroconversion ('vaccine take") among 166 Ghanaian infants after 2-3 doses of G1P[8] rotavirus vaccine during a vaccine trial, by HBGA status from saliva collected at age 4.1 years. Only secretor status was associated with seroconversion: 41% seroconversion for secretors vs 13% for nonsecretors; relative risk, 3.2 (95% confidence interval, 1.2-8.1; P = .016). Neither Lewis antigen nor salivary antigen blood type was associated with seroconversion. Likelihood of "take" for any particular rotavirus vaccine may differ across populations based on HBGAs.

PMID:
30357332
DOI:
10.1093/infdis/jiy573

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