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PLoS Med. 2018 Oct 24;15(10):e1002671. doi: 10.1371/journal.pmed.1002671. eCollection 2018 Oct.

Organophosphate exposures during pregnancy and child neurodevelopment: Recommendations for essential policy reforms.

Author information

Environmental Health Sciences Center and Department of Public Health Sciences, School of Medicine, University of California Davis, Davis, California, United States of America.
Natural Resources Defense Council, Washington, DC, United States of America.
George Washington University, Washington, DC, United States of America.
Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, United States of America.
School of Public Health, University of California Berkeley, Berkeley, California, United States of America.
BC Children's Hospital, Faculty of Health Sciences, Simon Fraser University, Vancouver, British Columbia, Canada.
Mailman School of Public Health and Children's Center for Environmental Health at Columbia University, New York, New York, United States of America.


In a Policy Forum, Irva Hertz-Picciotto and colleagues review the scientific evidence linking organophosphate pesticides to cognitive, behavioral, and neurological deficits in children and recommend actions to reduce exposures.

[Indexed for MEDLINE]
Free PMC Article

Conflict of interest statement

I have read the journal's policy and the authors of this manuscript have the following competing interests: IHP received NIH grants to study pesticides in relation to child neurodevelopment and mental health (R01ES015359, P01ES011269, UG3-OD023365, P30ES023513, EPA R829388, R833292) and grants from Ceres Trust Fund for work by Project TENDR to increase awareness of the scientific evidence regarding pesticides and neurodevelopment and to develop policy recommendations for reduction of such exposures. JBS is employed by NRDC, an environmental non-governmental organization. JBS, on behalf of NRDC, is providing scientific support for a lawsuit challenging USEPA approval of chlorpyrifos and other organophosphate pesticides. JBS, on behalf of NRDC, has expressed public positions on the scientific evidence of harm to human health and the environment from chlorpyrifos and other pesticides. NRDC and JBS have no direct or indirect financial or fiduciary interest in the manufacture or sale of any pesticide or chemical or methodology that is the subject of this manuscript. SE received grant funding related to environmental exposures and child neurodevelopment (UNC Chapel Hill Gillings Innovation Lab; NIH grants R01ES021777, P01ES09584; and EPA R8208270). DHB was supported by NIH grants to study pesticides in relation to child development and health (P01ES011269, UG3-OD023365, P30-ES023513, EPA R833292). BE and AB were supported by NIH grants to study pesticides and child neurodevelopment (R01ES026994, UG3OD023356, R24ES028529, R01ES020360; CIHR 241846, R01ES023067, R56ES023591). RW received funding from NIH for studies of environment including pyrethroid exposure and child development (R01ES021482, P01ES09600, EPA RD83214101). AB is a volunteer member of the Board of Trustees for The Organic Center, a non-profit organization addressing scientific issues about organic food and agriculture, and is a member of the USDA National Organic Standards Board. AB also advises organic and conventional food growers and processors on pesticide-related issues (unpaid). IHP and AB provided expert testimony (unpaid) to the California Senate Committee on Environmental Quality regarding commercial agricultural pesticide applications near schools; IHP provided expert consultation (unpaid) to the State of California Governor’s staff on use of chlorpyrifos in agriculture. IHP submitted information to the US EPA regarding regulation of chlorpyrifos in agriculture (unpaid). IHP is Co-Director of Project TENDR (unpaid), an organization seeking to reduce the incidence of child neurodevelopment disorders by eliminating or lowering exposures that increase risks. IHP serves on the Science Advisory Board to the California Breast Cancer Prevention Program (unpaid). BE served as a member, National Research Council of the National Academies, Committee to Review California's Risk Assessment for Pesticides (unpaid); and serves currently as a member of the National Advisory Environmental Health Sciences Council (unpaid). RW submitted information to the US EPA regarding regulation of chlorpyrifos (unpaid). RW is a founding member/advisor to International Society for Children's Health and the Environment (unpaid) and serves on the science advisory board for Women's Voices for the Earth (unpaid). BL has no competing interests to report.

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