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Virol J. 2018 Oct 23;15(1):163. doi: 10.1186/s12985-018-1082-8.

A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017.

Author information

1
Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, 13353, Berlin, Germany.
2
Ladoke Akintola University of Technology, Ogbomoso, Oyo State, P.M.B 4000, Nigeria.
3
Infectious Hazard Management Department, World Health Organization, Geneva, Switzerland.
4
Nigeria Centre for Disease Control, Plot 801, Ebitu Ukiwe Street, Jabi, Abuja, Nigeria.
5
Division of Viral Gastroenteritis and Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, 13353, Berlin, Germany. bockc@rki.de.
6
Institute of Tropical Medicine, University of Tübingen, 72074, Tübingen, Germany. bockc@rki.de.

Abstract

BACKGROUND:

In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the predominance of HEV genotypes 1 (HEV-1) and 2 (HEV-2). Molecular data of HEV-2 genomes are limited; therefore we characterized a HEV-2 strain of the outbreak in more detail.

FINDING:

The full-length genome sequence of an HEV-2 strain (NG/17-0500) from the outbreak was amplified using newly designed consensus primers. Comparison with other HEV complete genome sequences, including the only HEV-2 strain (Mex-14) with available complete genome sequences and the availability of data of partial HEV-2 sequences from Sub-Saharan Africa, suggests that NG/17-0500 belongs to HEV subtype 2b (HEV-2b).

CONCLUSIONS:

We identified a novel HEV-2b strain from Sub-Saharan Africa, which is the second complete HEV-2 sequence to date, whose natural history and epidemiology merit further investigation.

KEYWORDS:

Complete genome; HEV genotype 2; HEV subtype 2b; Hepatitis E virus; Nigeria; Outbreak

PMID:
30352598
PMCID:
PMC6199738
DOI:
10.1186/s12985-018-1082-8
[Indexed for MEDLINE]
Free PMC Article

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