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Endocr Connect. 2018 Oct 1. pii: /journals/ec/aop/ec-18-0308.xml. doi: 10.1530/EC-18-0308. [Epub ahead of print]

Blood pressure in 3-year-old girls associates inversely with umbilical cord serum 25-hydroxyvitamin D.

Author information

1
S Larsen, Clinical Research, Syddansk Universitet Det Sundhedsvidenskabelige Fakultet, Odense, 5230, Denmark.
2
C Dalgård, Department of Environmental Medicine, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
3
M Christensen, Clinical Research, Syddansk Universitet Det Sundhedsvidenskabelige Fakultet, Odense, Denmark.
4
S Lykkedegn, Hans Christian Andersen Children's Hospital, Odense Universitetshospital, Odense, Denmark.
5
L Andersen, Department of Obstetrics and Gynecology, Herlev Hospital, Herlev, Denmark.
6
M Andersen, Endocrinology, Odense Universitetshospital, Odense, Denmark.
7
D Glintborg, Endocrinology, Odense University Hospital, Odense , DK-5000, Denmark.
8
H Christesen, Hans Christian Andersen Children's Hospital, Odense Universitetshospital, Odense, Denmark.

Abstract

BACKGROUND:

Low foetal vitamin D status may be associated with higher blood pressure (BP) in later life.

OBJECTIVE:

To examine whether serum 25-hydroxyvitamin D2+3 (s-25OHD) in cord and pregnancy associates with systolic and diastolic BP (SBP; DBP) in children up to three years of age.

DESIGN:

Prospective, population-based cohort study.

METHODS:

We included 1594 singletons from the Odense Child Cohort with available cord s-25OHD and BP data at median age 3.7 months (48% girls), 18.9 months (44% girls), or three years (48% girls). Maternal s-25OHD was also assessed at gestational ages 12 and 29 weeks. Multiple regression models were stratified by sex a priori and adjusted for maternal educational level, season of birth and child height, weight and age.

RESULTS:

In 3-y-old girls, SBP decreased with -0.7mmHg (95%CI -1.1;-0.3, p=0.001) and DBP with -0.4mmHg (95%CI -0.7;-0.1, p=0.016) for every 10nmol/L increase in cord s-25OHD in adjusted analyses. Moreover, the adjusted odds of having SBP >90th percentile was reduced by 30% for every 10nmol/L increase in cord s-25OHD (p=0.004); and by 64% for cord s-25OHD above the median 45.1nmol/L (p=0.02). Similar findings were observed between pregnancy s-25OHD and 3-year SBP, cord s-25OHD and SBP at 18.9 months, and cord s-25OHD and DBP at three years. No consistent associations were observed between s-25OHD and BP in boys.

CONCLUSION:

Cord s-25OHD was inversely associated with SBP and DBP in young girls, but not in boys. Higher vitamin D status in foetal life may modulate BP in young girls. The sex difference remains unexplained.

PMID:
30352408
DOI:
10.1530/EC-18-0308
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