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J Gynecol Obstet Hum Reprod. 2019 Jan;48(1):19-24. doi: 10.1016/j.jogoh.2018.10.015. Epub 2018 Oct 22.

Anti Müllerian Hormone: More than a biomarker of female reproductive function.

Author information

1
Department of Reproductive Medicine and Fertility Preservation, Hôpital Jean Verdier, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance Publique - Hôpitaux de Paris, Bondy 93143, France.
2
Department of Reproductive Medicine and Fertility Preservation, Hôpital Jean Verdier, Hôpitaux Universitaires Paris-Seine-Saint-Denis, Assistance Publique - Hôpitaux de Paris, Bondy 93143, France; University Paris XIII, 93000 Bobigny, France.
3
Department of Reproductive Medicine and Fertility Preservation, Hôpital Antoine Béclère, Hôpitaux Universitaires Paris Sud, Assistance Publique - Hôpitaux de Paris, Clamart 92140, France; Université Paris-Sud, Université Paris Saclay, Le Kremlin Bicêtre 94276, France; Inserm U1133 Université Paris Diderot, Paris 75013, France. Electronic address: michael.grynberg@aphp.fr.

Abstract

Anti-Müllerian hormone (AMH), known for its role during sexual differentiation, is a dimeric glycoprotein that belongs to the transforming growth factor-β (TGF-β) family. AMH has recently been identified as a reliable marker of ovarian reserve that can help predict early ovarian follicle loss and menopause onset. AMH levels also reflect the effects of damaging gynecologic surgeries or gonadotoxic treatments such as chemotherapy on ovarian reserve. Furthermore, AMH participates in the diagnosis of certain diseases such as granulosa cell tumors or Polycystic Ovary Syndrome (PCOS). Currently used to establish patient profiles and predict ovarian response to stimulation, its role in ART techniques is crucial. Nevertheless, AMH appears to be a weak independent predictor of qualitative outcomes such as implantation, pregnancy, and live birth. As the reliability and reproducibility of AMH dosage have raised many doubts due to different existing standards and thresholds, an international consensus is still expected to improve AMH measurement and interpretation.

KEYWORDS:

AMH; Anti-Müllerian hormone; Menopause onset; Ovarian reserve

PMID:
30352309
DOI:
10.1016/j.jogoh.2018.10.015
[Indexed for MEDLINE]

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