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Food Chem Toxicol. 2019 Jan;123:72-97. doi: 10.1016/j.fct.2018.10.048. Epub 2018 Oct 22.

Ameliorative and protective effects of ginger and its main constituents against natural, chemical and radiation-induced toxicities: A comprehensive review.

Author information

1
NICM Health Research Institute, Western Sydney University, Westmead, 2145, NSW, Australia; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt. Electronic address: m.ali2@westernsydney.edu.au.
2
Department of Pharmaceutics, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.
3
Department of Pharmacology Department, Faculty of Veterinary Medicine, Cairo University, Giza, 12613, Egypt.
4
Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University (Assiut Branch), Egypt.
5
School of Chemistry, University of Wollongong, Wollongong, 2522, NSW, Australia.
6
Nanoscale Organisation and Dynamics Group, School of Science and Health, Western Sydney University, Penrith, NSW, 2751, Australia.
7
NICM Health Research Institute, Western Sydney University, Westmead, 2145, NSW, Australia.
8
NICM Health Research Institute, Western Sydney University, Westmead, 2145, NSW, Australia. Electronic address: C.li@westernsydney.edu.au.

Abstract

Fatal unintentional poisoning is widespread upon human exposure to toxic agents such as pesticides, heavy metals, environmental pollutants, bacterial and fungal toxins or even some medications and cosmetic products. In this regards, the application of the natural dietary agents as antidotes has engrossed a substantial attention. One of the ancient known traditional medicines and spices with an arsenal of metabolites of several reported health benefits is ginger. This extended literature review serves to demonstrate the protective effects and mechanisms of ginger and its phytochemicals against natural, chemical and radiation-induced toxicities. Collected data obtained from the in-vivo and in-vitro experimental studies in this overview detail the designation of the protective effects to ginger's antioxidant, anti-inflammatory, and anti-apoptotic properties. Ginger's armoury of phytochemicals exerted its protective function via different mechanisms and cell signalling pathways, including Nrf2/ARE, MAPK, NF-ƙB, Wnt/β-catenin, TGF-β1/Smad3, and ERK/CREB. The outcomes of this review could encourage further clinical trials of ginger applications in radiotherapy and chemotherapy regime for cancer treatments or its implementation to counteract the chemical toxicity induced by industrial pollutants, alcohol, smoking or administered drugs.

KEYWORDS:

Bio-toxin; Chemotherapy; Ginger; Protective effect; Radiation; Toxicity

PMID:
30352300
DOI:
10.1016/j.fct.2018.10.048
[Indexed for MEDLINE]

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