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Gene. 2019 Feb 5;684:47-52. doi: 10.1016/j.gene.2018.10.045. Epub 2018 Oct 22.

Multiple functions of Ikaros in hematological malignancies, solid tumor and autoimmune diseases.

Author information

1
Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, PR China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, PR China.
2
Department of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huai'an 223300, Jiangsu Province, PR China.; Key Laboratory of Hematology of Nanjing Medical University, Nanjing, 210029, Jiangsu Province, PR China. Electronic address: yuliangha@163.com.

Abstract

Ikaros, encoded by IKZF1 (Ikaros family zinc finger 1), is an important transcription factor in the control of lymphocyte specification and differentiation. Multiple functions of Ikaros have been exerted in almost all hematopoietic cell types, from stem cells to mature lymphoid and myeloid cells. Moreover, nonhematopoietic cells are also functional targets of Ikaros. Ikaros is essential for normal hematopoiesis, autoimmune and tumor suppression. Ikaros mutations were associated with lymphoblastic cells deficiency, autoimmunity and malignancies development, including hematological malignancies (leukemia) and solid tumors. This review focus on discuss the role of Ikaros in hematological malignancies, solid tumors and autoimmune diseases, and highlight the importance of Ikaros in cancer and immune diseases therapy.

KEYWORDS:

Autoimmune diseases; Ikaros; Leukemia; Mutations; Solid tumors

PMID:
30352248
DOI:
10.1016/j.gene.2018.10.045
[Indexed for MEDLINE]

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